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People
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Linda Turner Stern
Research InterestsI am interested in the motility of micro-organisms, especialy how bacteria swim (move as individuals in a liquid) and swarm (move in coordinated pack across a surface). During both behaviors the bacterial flagellar filament propels the bacterium. This filament is comprised of many copies of a single protein, called flagellin, arranged in a spiralling path on a cylindrical surface. The overall shape of the filament is helical. Extraordinarily this rigid helical propellor changes shape, called polymorphic transformations, as the bacterium swims and swarms. I enjoy thinking about and sorting out the relationship between applied motor torque, hydrodynamics, transformation and behaviors. I use fluorescent labeling, color imaging, and high speed imaging, http://www.jclabs.com/, to understand the role of the flagella in cell behavior.PublicationsChen, B.G., Turner L., and Berg H.C., “The wetting agent required for swarming in Salmonella enterica serovar typhimurium is not a surfactant.” J Bacteriol 2007, 189(23): 8750-8753. Epub 2007 Sep 28. Darnton, N., Turner, L., Rojevsky, S., and Berg H.C., “On Torque and Tumbling in Swimming Escherichia coli”, J. Bacteriol. 189(5): 1756-1764 (2007). Epub 2006 Dec 22. Yi, D.K., Kim, M.J., Turner, L., Breuer K.S., and Kim, D., “Colloid lithography-induced polydimethylsiloxane microstructures and their application to cell patterning”, Biotechnology Letters 28:169–173 (2006) DiLuzio, W.R., Turner, L, Mayer, M., Garstecki, P., Weibel, D.B., Berg, H.C., and Whitesides, G.M. “Escherichia coli swim on the right-hand side”, Nature 435:1271-4 (2005). Darnton, N., Turner, L., Breuer, K., and Berg H.C. “Moving fluid with bacterial carpets”, Biophys J. 86:1863-70 (2004). Turner, L., Ryu, W.S., and Berg, H.C. “Real-time imaging of fluorescent flagellar filaments”, J. Bacteriol. 182, 2793-2801 (2000). Turner, L., Samuel, A.D.T., Stern, A.S., and Berg, H.C. "Temperature dependence of switching of the bacterial flagellar motor by the protein CheY13DK106YW", Biophys. J. 77, 597-603 (1999). Scharf, B.E., Fahrner, K.A., Turner, L., and Berg, H.C., "Control of direction of flagellar rotation in bacterial chemotaxis," Proc. Natl. Acad. Sci. USA, 95, 201-206, (1998). Turner, L., Caplan, S.R., and Berg, H.C., "Temperature-Induced Switching of the Bacterial Flagellar Motor," Biophysical Journal, 71, 2227-2233, (1996). Berry, R.M., Turner, L., and Berg, H.C., "Mechanical Limits of Bacterial Flagellar Motors Probed by Electrorotation," Biophysical Journal, 69 (July 1995), 280-286, (1995). Berg, H.C. and Turner, L., "Cells of Escherichia coli Swim Either End Forward," Proc. Natl. Acad. Sci. USA, 92, 477-479, (1995). Berg, H.C. and Turner, L., "Torque Generated by the Flagellar Motor of Escherichia coli," Biophysical J., 65, 2201-2216, (1993). Berg, H.C. and Turner, L., "Selection of Motile Nonchemotactic Mutants of Escherichia coli by Field-flow Fractionation," Proc. Natl. Acad. Sci. USA, 88, 8145-8148, (1991). Berg, H.C. and Turner, L., "Chemotaxis of Bacteria in Glass Capillary Arrays," Biophysical J., 58, 919-930, (1990). Other Professional ActivitiesSymposium Organizer, Material Research Society, Symposium AA: Molecular Motors, Nanomachines and Engineered Systems, San Francisco, CA, April 17-21, 2006 Invited speaker, Frontiers in the Interaction between Physics and Biology, Spring 2004, Brown University, Providence, RI Contributor, National Nanotechnology Initiative, Workshop on NanoBiotechnology, Oct. 2003 Arlington, VA Invited speaker, American Society for Microbiology, Conference on Bio-, Micro-, and Nanosystems, July 2003, NYC, NY
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Last modified Tuesday, July 23, 2003.
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