People -Howard Berg -Karen Fahrner -Gabriel Hosu -Donna Lundberg -Veda Nathan -Tom Shimizu -Linda Turner Stern -Junhua Yuan

Tom Shimizu Postdoctoral Fellow, using BRET and FRET to study signaling in bacterial chemotaxis and developing mathematical models of the chemotaxis system. Also associated with the Center for Genomics Research.   Selected Publications Tu, Y., Shimizu, T.S. and Berg, H.C. Modeling the chemotactic response of Escherichia coli to time-varying stimuli. PNAS, in press. Sourjik, V., Vaknin, A., Shimizu, T.S. and Berg, H.C. In vivo measurement by FRET of pathway activity in bacterial chemotaxis. Methods Enzymol. 423, 365-391 (2007). Shimizu, T.S., Delalez, N., Pichler, K. and Berg, H.C. Monitoring bacterial chemotaxis by using bioluminescence resonance energy transfer: absence of feedback from the flagellar motors. Proc. Natl. Acad. Sci. USA 103, 2093-2097 (2006). Korobkova, E., Emonet, T., Vilar, J.M., Shimizu, T.S. and Cluzel, P. From molecular noise to behavioural variability in a single bacterium. Nature 428, 574-578 (2004). Shimizu, T.S., Aksenov, S.V. and Bray, D. A spatially extended stochastic model of the bacterial chemotaxis signalling pathway. J. Mol. Biol. 329, 291-309 (2003). Levin, M.D., Shimizu, T.S. and Bray, D. Binding and diffusion of CheR molecules within a cluster of membrane receptors. Biophys. J. 82, 1809-1817 (2002). Le Novère, N. and Shimizu, T.S. StochSim: modelling of stochastic biomolecular processes. Bioinformatics 17, 575-576 (2001). Shimizu, T.S., Le Novère, N., Levin, M.D., Beavil, A.J., Sutton, B.J. and Bray, D. Molecular model of a lattice of signalling proteins involved in bacterial chemotaxis. Nature Cell Biol. 2, 792-796 (2000). Morton-Firth, C.J., Shimizu T.S. and Bray D.   A free-energy-based stochastic simulation of the Tar receptor complex.  J. Mol. Biol. 286, 1059-1074 (1999).

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