We study the structure, dynamics and interactions of biomolecules in model systems. These systems can be seen as simplified, in vitro, versions of the real biological systems, yet they capture some essential components of the biological processes that they model. Our experiments are performed on the single-molecule or single-complex level, using methods such as FRET (Fluorescence Resonance Energy Transfer), Fluorescence lifetime, FCS (Fluorescence Correlation Spectroscopy) and patch clamping.

 

 

 

 

 

 

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In the figures: The dynamics and interactions of semi-flexible DNA polymers with a nanometer size pore are studied by
(1) threading the polymers through the pore or
(2) localizing the molecules in the pore using electrical fields.