The Rowland Institute at Harvard

Biophysical Chem Lab

Members

Jeff Hoch
Alan Stern

Research

LSIII
Human Prolactin

NMR Data Processing

Macromolecular
  Structure Calculations

Group Alumni

Peter Connolly
Claudio Chuaqui
Eric LaRosa
Kuo-Bin Li
George Maalouf
John Osterhout

Rowland Home

Jeffrey C. Hoch

Phone: (617) 497-4678
Fax: (617) 497-4627
E-mail: hoch@rowland.org

Authored Books

"NMR Data Processing"
Jeffrey C. Hoch and Alan S. Stern
Wiley-Liss, New York (1996).

Edited Books

"Computational Aspects of the Study of Biological Macromolecules by Nuclear Magnetic Resonance Spectroscopy"
Jeffrey C. Hoch, Flemming F. Poulsen, and Christina Redfield, eds.
Plenum Press, New York (1991).

Peer-reviewed Articles

"Multiple-quantum magic-angle spinning spectroscopy using nonlinear sampling." Rovnyak D, Filip C, Itin B, Stern AS, Wagner G, Griffin RG, Hoch JC. J Magn Reson 161, 43-55 (2003)

"De novo Backbone and Sequence Design of an Idealized alpha/beta-barrel Protein: Evidence of Stable Tertiary Structure" F. Offredi, F. Dubali, P. Kischel. K. Sarinski, Alan S. Stern, C. Van de Weerdt, Jeffrey C. Hoch, C. Prosperi, J.M. François, S.L. Mayo, and J.A. Martial, J Mol Biol 325, 163-174 (2003)

"Modern spectrum analysis in multidimensional NMR spectroscopy. Comparison of linear-prediction extrapolation and maximum-entropy reconstruction" Alan S. Stern, Kuo-Bin Li, and Jeffrey C. Hoch, J. Am. Chem. Soc. 124, 1982-1993 (2002)

"New Carbon-Detected Protein NMR Experiments Using CryoProbes" Zach Serber, Christian Richter, Detlef Moskau, Jean-Marc Böhlen, Tobias Gerfin, Daniel Marek, Markus Häberli, Ludivica Baselgia, Frank Laukien, Alan S. Stern, Jeffrey C. Hoch, and Volker Dötsch, J. Am. Chem. Soc.122, 3554-3555 (2000)

"Distributed Parallel Processing for Multidimensional Maximum Entropy Reconstruction"
Kuo-Bin Li, Alan S. Stern, and Jeffrey C. Hoch
J. Magn. Reson., 134, 161-163 (1998).

"Quantification of Maximum-Entropy Spectrum Reconstructions"
Peter Schmieder, Alan S. Stern, Gerhard Wagner, and Jeffrey C. Hoch
J. Magn. Reson., 125, 332-339 (1997).

Photograph of Jeff Hoch.

"The Solution Structure of LSIII, a Long Neurotoxin from the Venom of Laticauda semifasciata"
Peter J. Connolly, Alan S. Stern, and Jeffrey C. Hoch
Biochemistry 35, 418-426 (1996).

"Estimating Protein Fold from Incomplete and Approximate NMR Data"
Peter J. Connolly, Alan S. Stern, and Jeffrey C. Hoch
J. Am. Chem. Soc., 116, 2675-2676 (1994).

Up and down arrows.Up.Down.

"Improved resolution in triple-resonance spectra by non-linear sampling in the constant time domain"
Peter Schmieder, Alan S. Stern, Gerhard Wagner, and Jeffrey C. Hoch
J. Biomol. NMR, 4, 483-490 (1994).

"Application of non-linear sampling schemes to COSY-type spectra"
Peter Schmieder, Alan S. Stern, Gerhard Wagner, and Jeffrey C. Hoch
J. Biomol. NMR, 3, 569-576 (1993).

"Holographic Methods in X-ray Crystallography III. First Numerical Results"
George J. Maalouf, Jeffrey C. Hoch, Alan S. Stern, Hanna Szoke, and Abraham Szoke
Acta Cryst., A49,866-871 (1993).

"A method for determining overall protein fold from NMR distance restraints"
Jeffrey C. Hoch and Alan S. Stern
J. Biomol. NMR 2, 535-543 (1992).

"A New, Storage-efficient Algorithm for Maximum Entropy Spectrum Reconstruction"
Alan S. Stern and Jeffrey C. Hoch
J. Magn. Reson., 97, 255-270 (1992).

"Maximum Entropy and The Nearly Black Object"
David L. Donoho, Iain M. Johnstone, Jeffrey C. Hoch, and Alan S. Stern
J. R. Statist. Soc. B54, 41-81 (1992).

"Characterization of the Structural Properties of a1B, a Peptide Designed to Form a Four-Helix Bundle"
John J. Osterhout, Jr., Tracy Handel, George Na, Arazdordi Toumadje, Robert C. Long, Peter J. Connolly, Jeffrey C. Hoch, W. Curtis Johnson, Jr., David Live, and William F. DeGrado
J. Amer. Chem. Soc., 114, 331-337 (1992).

"Photochemical Oxidation of Tryptophan Residues During Photo-CIDNP Experiments"
Peter J. Connolly and Jeffrey C. Hoch
J. Magn. Reson., 95, 165-173 (1991).

"Does the maximum entropy method improve sensitivity?"
David. L. Donoho, Iain M. Johnstone, Alan S. Stern, and Jeffrey C. Hoch
Proc. Natl. Acad. Sci. USA, 87, 5066 (1990).

"Maximum Entropy Reconstruction of Complex (Phase-Sensitive) Spectra"
Jeffrey C. Hoch, Alan S. Stern, David L. Donoho, and Iain M. Johnstone
J. Magn. Reson., 86, 236 (1990).

"Symmetry Recognition Applied to Two-Dimensional NMR Data"
Jeffrey C. Hoch, Shen Hengyi, Mogens Kjaer, Svend Ludvigsen, and Flemming M. Poulsen
Carlsberg Res. Commun., 52, 111-122 (1987).

"Interpretation of Ring-Current Shifts in Proteins: Application to Phage l Repressor"
Michael A. Weiss and Jeffrey C. Hoch
J. Magn. Reson., 72, 324-333 (1987).

"Maximum Entropy Signal Processing of Two Dimensional NMR Data"
J. Magn. Reson., 64, 436-440 (1985).

"Quantitative Measurement Using Pure-Phase Two-Dimensional Exchange Spectroscopy"
Edward T. Olejniczak, Jeffrey C. Hoch, Christopher M. Dobson, and Flemming M. Poulsen
J. Magn. Reson., 64, 199-206 (1985).

"Vicinal Coupling Constants and Protein Dynamics"
Jeffrey C. Hoch, Christopher M. Dobson, and Martin Karplus
Biochemistry, 24, 3831-3841(1985).

Up and down arrows.

"Chemical Shifts of Aromatic Protons in Protein NMR Spectra"
Christina Redfield, Jeffrey C. Hoch, and Christopher M. Dobson
FEBS Lett., 159, 132-136 (1983).

"Fluctuations and Averaging of Proton Chemical Shifts in the Bovine Pancreatic Trypsin Inhibitor"
Jeffrey C. Hoch, Christopher M. Dobson, and Martin Karplus
Biochemistry, 21, 1118-1125 (1982).

"Structures and Dynamics of Proteins by Proton NMR. Application of Nuclear Overhauser Effects to Lysozyme"
M. Delepierre, Christopher M. Dobson, Jeffrey C. Hoch, Edward T. Olejniczak, Flemming M. Poulsen, R.G. Ratcliffe, and Christina Redfield
Biomolecular Stereodynamics, 2, 237-253 (1981).

"Conformations and Conformational Dynamics of Proteins in Solution Studied by Nuclear Magnetic Double Resonance"
Christopher M. Dobson, Jeffrey C. Hoch, Edward T. Olejniczak, and Flemming M. Poulsen
Biophys. J., 32, 625-627 (1980).

"A Structural Study of the Hydrophobic Box Region of Lysozyme in Solution Using Nuclear Overhauser Effects"
Flemming M. Poulsen, Jeffrey C. Hoch, and Christopher M. Dobson
Biochemistry, 19, 2597-2607 (1980).

"Kinetics of Chloride Substitution into Bis(oxalato)platinate(II) Ion"
Jeffrey C. Hoch and Ronald M. Milburn
Inorg. Chem., 18, 886-887 (1979).

"Investigation of the Structure of the Reaction Center in Photosynthetic Systems by Optical Detection of Triplet State Magnetic Resonance"
Richard H. Clarke, Robert E. Connors, Harry A. Frank, and Jeffrey C. Hoch
Chem. Phys. Lett., 45, 523-528 (1977).

Invited Book Chapters, Reviews, and Commentaries

"Maximum Entropy Reconstruction, Spectrum Analysis and Deconvolution in Multidimensional Nuclear Magnetic Resonance" Jeffrey C. Hoch and Alan S. Stern, Meth. Enzym., 338, 159-178 (2001).

"Signatures and Consequences of Hydrophobic Strain in Globular Proteins" Jeffrey C. Hoch and Alan S. Stern, in Dynamics, Structure, and Function of Biological Macromolecules, O. Jardetzky and M.D. Finucane, eds., IOS Press, Amsterdam, (2001).

"Fitting Protein Structures to Experimental Data: Lessons from Before Your Mother Was Born", in Protein Dynamics, Function, and Design, O. Jardetzky and J.-F. Lefevre, Eds., Plenum Press, New York (1998).

"Solution Structure of the Long Neurotoxin LSIII, With Possible Implications for Binding to the Acetylcholine Receptor"
Peter J. Connolly, Alan S. Stern, and Jeffrey C. Hoch
in Dynamics and the Problem of Recognition in Biological Macromolecules, O. Jardetzky and J.-F. Lefevre, Eds., Plenum Press, New York (1996).

"Maximum Entropy Reconstruction in NMR"
Jeffrey C. Hoch and Alan S. Stern
in Encyclopedia of NMR, D.M. Grant and R.K. Harris, eds., John Wiley & Sons, Chichester (1996).

"Bons Baisers de Boston"
Jeffrey C. Hoch
Plaisirs de la Table, 8, 30-31 (1993).

"An Amateur Looks at Error Analysis in the Determination of Protein Structure by NMR"
Jeffrey C. Hoch
in Computational Aspects of the Study of Biological Macromolecules by NMR Spectroscopy, Hoch, J.C., Redfield, C., and Poulsen, F.M., eds.
Plenum, New York, 253-267 (1991).

"Computer-Aided Analysis of Protein NMR Spectra"
Jeffrey C. Hoch, Alan S. Stern, and Christina Redfield
Curr. Op. Struct. Biol., 1, 1036-1041 (1991).

"Computer Assisted Assignment of Two-Dimensional NMR Spectra of Proteins"
Jeffrey C. Hoch, Michael M. Burns, and Christina Redfield
Frontiers of NMR in Molecular Biology, p. 167, Alan R. Liss, Inc.(1990).

"Modern Spectrum Analysis in NMR: Alternatives to FT"
Jeffrey C. Hoch, Meth. Enzym., 176, 216-241 (1989).

"Structural Determination of Biological Macromolecules by Three-Dimensional NMR"
Jeffrey C. Hoch, Physics Today, 42, S19 (1989).

Copyright © 2001 The Rowland Institute at Harvard.

Last modified Thursday, October 09, 2003.