Photomedicine and Photobiology Group Abstracts Papers Patents	Louis Cincotta
	Email: cincotta@rowland.org
	Abstracts Hasan, T.; Yarmush, M.; Foley, J.; Cincotta, L.; Oseroff, A., "Selective Targeting of Laser Damage with Exogenous Chromophores Coupled to Monoclonal Antibodies," 189th National Meeting of the American Chemical Society, p 50 [MEDF], (1985). Valdes-Aguilera, O.; Kochevar, I.E.; Foley, J.; Cincotta, L., "Spectral Characterization of the Mitochondrial Dye 1,1 -(2-Ethyl-1,3-dioxolane)kryptocyanine (EDKC)," Photochem. Photobiol., 41 Suppl., [TPM-D9] p. 585 (1985). Oseroff, A.R.; Ohuoha, D.; McAuliffe, D.; Ara, G.; Shea, C.; Foley, J.; Cincotta, L., "Selective Mitochondrial Photolysis (SMPL): A New Mitochondrial Specific Photochemotherapy," Photochem. Photobiol., 41 Suppl., [WAM-D8], p 755 (1985). Valdes-Aguilera, O.; Cincotta, L.; Foley, J.; Kochevar, I.E., "Active Oxygen Species in the Photolysis of 1,1'-(2-Ethyl-1,3-dioxolane)kryptocyanine (EDKC)," Photochem. Photobiol. 43 suppl., [TAM-D4], p 485 (1986). Ara, G.; Aprille, J.; Foley, J.; Cincotta, L.; Oseroff, A.R., "A Kryptocyanine Dye Causes Photosensitized, Site-Specific Inhibition of Mitochondrial Electron Transport, and Alters ATP Levels and Cell Cycle Distributions," Photochem. Photobiol. 43 suppl., [TAM-D9], p 495 (1986). Ara, G.; Cincotta, L.; Foley, J.; Hruza, G.; Anderson, R.R., "Phototoxicity of Melanoma Cells by High-Intensity Ruby Laser Radiation," Clayton Foundation Conference on Photodynamic Therapy, February 15-19, 1987, Los Angeles, CA, 51. Cincotta, L.; Foley, J.W.; Cincotta, A.H., "Novel Red-Absorbing Benzophenoxonium and Benzophenothiazonium Photosensitizers," Clayton Foundation Conference on Photodynamic Therapy, February 15-19, 1987, Los Angeles, CA, 122. Oseroff, A.R.; Ohuoha, D.; Ara, G.; Foley, J.; Cincotta, L., "Selective Carcinoma Cell Photolysis (SCCP). The Preferential Light-Induced Killing of Carcinoma Cells Due to Mitochondrial Accumulation of Cationic Dyes is Potentiated by 2-Deoxy-d-glucose (2-DG) and Hyperthermia," Clayton Foundation Conference on Photodynamic Therapy, February 15-19, 1987, Los Angeles, CA, 109. Ohuoha, D.C.; Cincotta, L.; Foley, J.; Oseroff, A.R., "Enhancement of EDKC Phototoxicity by Cellular Glutathione Depleting Agents Buthionine Sulfoxine (BSO) and Diethyl Maleate (DEM)," Clayton Foundation Conference on Photodynamic Therapy, February 15-19, 1987, Los Angeles, CA, 123. Oseroff, A.R.; Ohuoha, D.; Ara, G.; Kane, S.B.; Foley, J.; Cincotta, L., "The Carcinoma Cell-Selective Phototoxicity of EDKC is Potentiated by Hypoxia and Metronidazole," Photochem. Photobiol., 45 suppl., [THPM-C4], p1015 (1987). Cincotta, A.H.; Cincotta, L.; Foley, J.W., "Novel Benzophenothiazines in the Photodynamic Therapy of Tumors," 3rd Biennial Meeting of the International Photodynamic Association (IPA), July 17-21, 1990, Buffalo, New York. Foley, J.W.; Cincotta, L., "Novel Cationic Photochemotherapeutic Agents: Correlation of Singlet Oxygen Quantum Yields with Molecular Structure of Phenoxazine Derivatives," 3rd Biennial Meeting of the International Photodynamic Association (IPA), July 17-21, 1990, Buffalo, New York. Lin, C.-W.; Shulok, J.R.; Wong, Y.K.; Cincotta, L.; Foley, J.W., "Mechanisms of Cellular Uptake and Phototoxicity of New Cationic Phenoxazine Photosensitizers," 3rd Biennial Meeting of the International Photodynamic Association (IPA), July 17-21, 1990, Buffalo, New York. Cincotta, A.H.; Lampros, L.; Cincotta, L.; Foley, J.; MacEachern, T., "Novel Benzophenoxazine Analogs Are Efficacious and Unique Photochemotherapeutic Drugs," XVII MGH Research Symposium and Poster Session, January 20, 1993. Gut, I.G.; Redmond, R.W.; Foley, J.; Cincotta, L.; Kochevar, I.E., "A Comparative Investigation of the Photophysical Properties of Substituted Nile Blue A Derivatives," XVII MGH Research Symposium and Poster Session, January 20, 1993. Cincotta, L.; Foley, J.W.; Szeto, D.L.; Cincotta, A.H., "Chronophototherapy with EtNBS for the Treatment of Solid Tumors," Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, Proceedings SPIE 2392, (1995) 124. Cincotta, L., Foley, J., Szeto, D., Lampros, E., Cincotta, A.H., "Combination Phototherapy using a Benzoporphyrin Derivative (BPD-MA) and a Benzophenothiazine (EtNBS)", Photochem. Photobiol., 61 suppl., [TPM-E5], p 67s, (1995). Kwangsukstith, C.; Ross, E.V.; Cincotta, L.; Gonzalez, S.; Kollias, N., "Photodynamic Effects of a Benzophenothiazine on UV-Induced Murine Squamous Cell Carcinoma," Photochemistry and Photobiology (Program and Abstracts, 24th Annual Meeting of the American Society for Photobiology, Atlanta, GA, June 15-20, 1996), 63, 70s, (1996). Wagner, S., Robinette, D., Skripchenko, A., Cincotta, L., "Virus inactivation by Phenothiazines in Red Cell Suspensions", Photochem. Photobiol., 65 suppl., [SAM-F11], p 9s, (1997). Wagner, S., Skripchenko, A., Robinette, D., Mallory, D., Foley, J., Cincotta, L., "Virus Photoinactivation by Dimethlymethylene Blue (DMMB) in Red Cell Suspensions", Photochem. Photobiol., 67 suppl., [SAM-B3], p 125, (1998). Papers Oseroff, A.R.; Ohuoha, D.; Ara, G.; McAuliffe, D.; Foley, J.; Cincotta, L., "Intramitochondrial Dyes Allow Selective in vitro Photolysis of Carcinoma Cells," Proc. Natl. Acad. Sci. USA, 83, 9729-9733, (1986). Valdes-Aguilera, O.; Cincotta, L.; Foley, J.; Kochevar, I.E., "Photobleaching of a Cyanine Dye in Solution and in Membranes," Photochem. Photobiol., 45, 337-344, (1987). Cincotta, L.; Foley, J.W.; Cincotta, A.H., "Novel Red Absorbing Benzo[a]phenoxazinium and Benzo[a]phenothiazinium Photosensitizers: in-vitro Evaluation," Photochem. Photobiol., 46, 751-758, (1987). Oseroff, A.R.; Ara, G.; Ohuoha, D.; Aprille, J.; Bommer, J.C.; Yarmush, M.L.; Foley, J.; Cincotta, L., "Strategies for Selective Cancer Photochemotherapy: Antibody-Targeted and Selective Carcinoma Cell Photolysis," Photochem. Photobiol., 46 (1), 83-96, (1987). Foley, J.W.; Cincotta, L.; Cincotta, A.H., "Structure and Properties of Novel Benzo[a]phenoxazinium Photochemotherapeutic Agents," Proceedings SPIE, 847, 90-95, (1987). Cincotta, L.; Foley, J.W.; Cincotta, A.H., "Novel Phenothiazinium Photosensitizers for Photodynamic Therapy," Advances in Photochemotherapy, Proceedings SPIE 997, (1988) 145-153. Cincotta, A.H.; Cincotta, L.; Foley, J.W., "Novel Benzophenothiazinium Photosensitizers: Preliminary in-vivo Results," Photodynamic Therapy: Mechanisms II, Proceedings SPIE 1203, (1990) 202-210. Lin, C.-W.; Shulok, J.R.; Wong, Y.; Cincotta, L.; Foley, J.W., "Uptake Retention and Phototoxicity of Cationic Phenoxazine Photosensitizers in Tumor Cells in Culture," Photodynamic Therapy: Mechanisms II, Proceedings SPIE 1203, (1990) 287-292. Lin, C.-W.; Shulok, J.R.; Wong, Y.; Cincotta, L.; Foley, J.W., "Uptake Retention and Phototoxicity of Cationic Phenoxazine Photosensitizers in Tumor Cells in Culture," Proceedings SPIE, 1203, 287-292, (1990). Lin, C.-W.; Shulok, J.R.; Wong, Y.-K.; Schanbacher, C.F.; Cincotta, L.; Foley, J.W., "Photosensitization, Uptake, and Retention of Phenoxazine Nile Blue Derivatives in Human Bladder Carcinoma Cells," Cancer Res., 51, 1109-1116, (1991). Foley, J.W.; Cincotta, L., "Evaluation of Nile Blue E Chalcogen Analogs as PDT Agents," Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, Proceedings SPIE 1426, (1991) 208-215. Lin, C.-W.; Shulok, J.R.; Kirley, S.D.; Cincotta, L.; Foley, J.W., "Nile Blue Derivatives as Lysosomotropic Photosensitizers," Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, Proceedings SPIE 1426, (1991) 216-227. Lin, C.-W.; Shulok, J.R.; Kirley, S.D.; Cincotta, L.; Foley, J.W., "Lysosomal Localization and Mechanism of Uptake of Nile Blue Photosensitizers in Tumor Cells," Cancer Res., 51, 2710-2719, (1991). Cincotta, L.; Foley, J.W.; Cincotta, A.H., "Phototoxicity, Redox Behavior, and Pharmacokinetics of Benzophenoxazine Analogues in EMT-6 Murine Sarcoma Cells," Cancer Res., 53, 2571-2580, (1993). Lin, C.-W.; Shulok, J.R.; Kirley, S.D.; Bachelder, C.M.; Flotte, T.J.; Sherwood, M.E; Cincotta, L.; Foley, J.W., "Photodynamic Destruction of Lysosomes Mediated by Nile Blue Photosensitizers," Photochem. Photobiol., 58, 81-91, (1993). Cincotta, L.; Foley, J.W.; MacEachern, T.; Lampros, E.; Cincotta, A.H., "Novel Photodynamic Effects of a Benzophenothiazine on Two Different Murine Sarcomas," Cancer Res., 54, 1249, (1994). Cincotta, L.; Szeto, D.; Lampros, E.; Hasan, T.; Cincotta, A.H., "Benzophenothiazine and Benzoporphyrin Derivative Combination Phototherapy Effectively Eradicates Large Murine Sarcomas," Photochemistry and Photobiology, 63 (2), 229-237, (1996). Wagner, S.J.; Skripchenko, A.; Robinette, D.; Foley, J.W.; Cincotta, L., "Factors Affecting Virus Photoinactivation by a Series of Phenothiazine Dyes," Photochemistry and Photobiology, 67, 343-349, (1998). Frimberger, A.E.; Moore, A.S.; Cincotta, L.; Cotter, S.M.; Foley, J.W., "Photodynamic therapy of naturally occuring tumors in animals using a novel benzophenothiazine photosensitizer," Clinical Cancer Research, 4, 2207-2218, (1998). Wagner, S., Skripchenko, A., Robinette, D., Mallory, D., Cincotta, L., "Preservation of Red Cell Properties after Virucidal Phototreatment with Dimethylmethylene Blue", Transfusion, 38, 729-737, (1998). Hendrzak-Henion, J.A., Knisely, T.L., Cincotta, L., Cincotta, E., Cincotta, A.H., "Role of the Immune System in Mediating the Antitumor effect of Benzophenothiazine Photodynamic Therapy", Photochem. Photobiol. 69, 575-581 (1999). Gloster, D., Cincotta, L., Foley, J.W., "Design, Synthesis, and Photophysical Characterization of Novel Pentacyclic Red Shifted Azine Dyes", J. Heterocycl. Chem., 36, 25-32 (1999). Walworth, L, Cincotta, L., Scarpetti, J. "Efficiency of polarization optics in viewing stereoscopic images." Stereoscopic Displays and Virtual Reality Systems VIII, January 22-25, 2001,San Jose, CA, (SPIE, Vol. 4297, 2001), 8. Patents Oseroff, A.; Foley, J.; Cincotta, L.; Parrish, J.A., "Light-Induced Killing of Carcinoma Cells," U.S. Patent no. 4,651,739 (1987). Foley, J.W.; Cincotta, L., "Photo-inactivation of Cancer Cells," U.S. Patent no. 4,962,197 (1990). Cincotta, A., Cincotta, L., "Growth Inhibition and Eradication of Solid Tumors Using Neuroendocrine Resetting Therapy", USA application #60/016,619 (1996). Cincotta, A.H., Cincotta, L., "Benzophenothiazine and Benzoporphyrin Dye Combination Photdynamic Therapy of Tumors", USA Patent #5,952,329 (2000). Cincotta, L., Cincotta, A.H., "Treatment of Solid Tumors Using Tumor Cells Treated with Photosensitizers or Antigen Isolated Therefrom", USA application #60/087,865 (1998). Wagner, S., Cincotta, L., "Intracellular and Extracellular Decontamination of Whole Blood and Blood Components by Amphiphilic Phenothiazin-ium Dyes Plus Light", USA Patent #6,030,767 (2000).

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