Single-molecule Force Studies

Wesley P. Wong, P.I.


Our group studies how biological systems work at the nanoscale, and the physical laws that govern their behavior. We are particularly interested in the weak, non-covalent interactions between and within biological molecules (e.g. base-pairing in nucleic acids, receptor-ligand bonding, protein folding, etc.), and the coupling of these interactions to mechanical force. To investigate these issues, we develop and apply novel techniques in single-molecule manipulation, detection, and analysis, including optical tweezers methods and high-resolution optical detection.

Please take a look around our website to learn more. Read more about our research, learn about our members, peruse our publications, and find out about new happenings in our group. Or follow these links to: contact us, learn more about the Rowland, or explore Harvard University. And come back soon, as we are currently adding to and improving our new website.

Welcome to the Single-molecule Force Studies Group

Our group develops and applies new techniques in single-molecule manipulation to study biological systems at the nanoscale.

Publication in Science on VWF and the regulation of hemostasis.News/Entries/2009/6/5_new_publication__vwf_and_the_regulation_of_blood_clotting.html
Introducing massively parallel force measurements with single-molecule centrifugation!News/Entries/2010/6/2_New_publication__single-molecule_centrifugation.html
News! We’ve moved to Harvard Medical School and the Immune Disease Institute!News/Entries/2011/4/11_Were_moving_to_Harvard_Medical_School_and_IDI....html
Please visit our new website at
Just published: we’ve developed a single-molecule mechanical switch using DNA self-assemblyResearch/Entries/2012/3/10_NANOENGINEERING_FUNCTIONAL_SINGLE-MOLECULE_TOOLS_WITH_DNA_SELF-ASSEMBLY.html