Single-molecule Force Studies
Wesley P. Wong, P.I.
Single-molecule Force Studies
Wesley P. Wong, P.I.
publications
W. Zhao, C.H. Cui, S. Bose, D. Guo, C. Shen, W.P. Wong, K. Halvorsen, O.C. Farokhzad, G.S.L. Teo, J.A. Phillips, D.M. Dorfman, R. Karnik, & J.M. Karp, A bioinspired multivalent DNA network for capture and release of cells, Proc. Natl. Acad. Sci. USA (2012). [link]
J. Pelletier*, K. Halvorsen*, B.-Y. Ha, R. Paparcone, S. Sandler, C. Woldringh, W.P. Wong^, & S. Jun^, Physical manipulation of the Escherichia coli chromosome reveals its soft nature, Proc. Natl. Acad. Sci. USA 109 (4), E2649-E2656 (2012).
(*equal contribution, ^co-corresponding authors). [pdf] [link]
K. Halvorsen and W.P. Wong, Binary DNA Nanostructures for Data Encryption. PLoS ONE 7 (9), e44212 (2012). [link]
K. Halvorsen, D. Schaak, and W.P. Wong, (2011), Nanoengineering a single-molecule mechanical switch using DNA self-assembly, Nanotechnology 22 (49):494005 (2011). [pdf] [link]
K. Halvorsen, W.P. Wong, “Massively parallel single-molecule manipulation using centrifugal force,” Biophysical Journal 98 (11), L53-L55 (2010). [pdf]
D. Cheng, K. Halvorsen, W.P. Wong, “High-precision microsphere sorting using velocity sedimentation,” Reviews of Scientific Instruments 81, 026106 (2010). [pdf]
X. Zhang*, K. Halvorsen*, C.-Z. Zhang, W.P. Wong^, and T.A. Springer^, “Mechanoenzymatic cleavage of the ultralarge vascular protein, von Willebrand Factor,” Science 324 (5932), 1330-1334 (2009). [pdf]
(*contributed equally ^co-corresponding authors)
E. Evans, K. Halvorsen, K. Kinoshita, and W.P. Wong, “A new approach to analysis of single molecule force measurements,” in Handbook of Single Molecule Biophysics, P. Hinterdorfer, ed., Springer (2009). [pdf] [link]
W.P. Wong*^ and K. Halvorsen*, "Beyond the frame rate: Measuring high-frequency fluctuations with light intensity modulation," Optics Letters 34 (3), 277-279 (2009). [pdf] (*contributed equally ^corresponding author)
V. Heinrich*, W.P. Wong*, K. Halvorsen, and E. Evans, “Imaging biomolecular interactions by fast three-dimensional tracking of laser-confined carrier particles,” Langmuir 24, 1194-1203 (2008). [pdf] (*contributed equally)
K. Halvorsen, “Probing weak single-molecule interactions: development and demonstration of a new instrument,” Ph. D Thesis (advisor: E. Evans), Department of Biomedical Engineering, Boston University, USA (2007). [pdf]
W.P. Wong*^ and K. Halvorsen*, “The effect of integration time on fluctuation measurements: calibrating an optical trap in the presence of motion blur,” Optics Express 14 (25), 12517-12531 (2006). [pdf]
(*contributed equally ^corresponding author)
W.P. Wong, “Exploring single-molecule interactions through 3D optical trapping and tracking: from thermal noise to protein refolding,” Ph. D Thesis (advisors: D.R. Nelson and E. Evans), Department of Physics, Harvard University, USA (2006). [pdf]
W.P. Wong and E. Evans, “Rare returns on lost effort,” Nature 437, 198-199 (2005).[pdf]
W.P. Wong, V. Heinrich, and E. Evans, “Exploring reaction pathways of single-molecule interactions through the manipulation and tracking of a potential-confined microsphere in three dimensions,” Mat. Res. Soc. Symp. Proc. 790, P5.1.1-P5.1.12 (2004). [pdf]
W.P. Wong, “Modelling a Tethered Polymer Loop: Shape and thickness compressibility,” Master’s Thesis, The University of British Columbia, Canada (2001). [pdf]
W.P. Wong and K. Halvorsen, “Nucleic acid-based linkers for detecting and measuring interactions,” US provisional patent application 61/556,194 (2011).
W.P. Wong and K. Halvorsen. "(Miniature) Spinning force apparatus,” US provisional patent application 61350088 (2010).
W.P. Wong and K. Halvorsen, "Spinning force apparatus,” US patent 12/326,279 (2008).
W.P. Wong and K. Halvorsen, "Methods, apparatus and systems for determining power spectral density of a signal via modulation of the signal,” US provisional patent application 61086,336 (2008).
patents