Sophia Shi
2025-present
Neurobiology & Glycoscience
sophia_shi@fas.harvard.edu
617-496-0949
The Shi Lab seeks to uncover molecular mechanisms that drive brain aging and neurodegenerative diseases. We specialize in decoding glycans—complex carbohydrates that decorate our cells and permeate our brain’s extracellular environment. Despite their fundamental biological roles, glycans remain one of the most understudied components of neurobiology. We aim to change that using interdisciplinary approaches that combine advanced microscopy (confocal, electron, in vivo multi-photon), viral vectors, protein engineering, mouse models, and multi-omics analyses.